Timing of dornase alfa inhalation for cystic fibrosis

CONCLUSIONS: The current evidence derived from a small number of participants does not indicate that inhalation of dornase alfa after airway clearance techniques is more or less effective than the traditional recommendation to inhale nebulised dornase alfa 30 minutes prior to airway clearance techniques, for most outcomes. For children with well-preserved lung function, inhalation before airway clearance may be more beneficial for small airway function than inhalation after. However, this result relied on a measure with high variability and trials with variable follow-up. In the absence of strong evidence to indicate that one timing regimen is better than another, the timing of dornase alfa inhalation can be largely based on pragmatic reasons or individual preference with respect to the time of airway clearance and time of day. Further research is warranted.PMID:33686652 | DOI:10.1002/14651858.CD007923.pub6

Source: Cochrane Database of Systematic Reviews - March 9, 2021 Category: General Medicine Authors: Ruth Dentice Mark Elkins Source Type: research