A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike [Microbiology]

The current pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights an urgent need to develop a safe, efficacious, and durable vaccine. Using a measles virus (rMeV) vaccine strain as the backbone, we developed a series of recombinant attenuated vaccine candidates expressing various forms of the...

Source: Proceedings of the National Academy of Sciences - March 9, 2021 Category: Science Authors: Mijia Lu, Piyush Dravid, Yuexiu Zhang, Sheetal Trivedi, Anzhong Li, Olivia Harder, Mahesh KC, Supranee Chaiwatpongsakorn, Ashley Zani, Adam Kenney, Cong Zeng, Chuanxi Cai, Chengjin Ye, Xueya Liang, Masako Shimamura, Shan-Lu Liu, Asuncion Mejias, Octavio R Tags: Microbiology, Coronavirus (COVID-19) Biological Sciences Source Type: research