Comparison of a thymine challenge test and endogenous uracil –dihydrouracil levels for assessment of fluoropyrimidine toxicity risk

ConclusionsThe endogenous uracil-based parameters, adjusted to CrCL, were more predictive of increased risk of severe fluoropyrimidine toxicity thanDPYD genotyping. However, endogenous U measurement detected fewer cases of severe toxicity than the THY challenge test.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research