Artificial neural networks for simultaneously predicting the risk of multiple co ‐occurring symptoms among patients with cancer

AbstractPatients with cancer often exhibit multiple co ‐occurring symptoms which can impact the type of treatment received, recovery, and long‐term health. We aim to simultaneously predict the risk of three symptoms: severe pain, moderate‐severe depression, and poor well‐being in order to flag patients who may benefit from pre‐emptive early sy mptom management. This was a retrospective population‐based cohort study of adults diagnosed with cancer between 2008 and 2015. We developed and tested an Artificial Neural Network (ANN) model to predict the risk of multiple co‐occurring symptoms within 6 months after diagnosis. The ANN model d erived from a training cohort was assessed on an independent test cohort for model performance based on sensitivity, specificity, accuracy, AUC, and calibration. The mutually exclusive training and test cohorts consisted of 35,606 and 10,498 patients, respectively. The area under the curve for the r isk of experiencing severe pain, moderate‐severe depression, and poor well‐being were 71%, 73%, and 70%, respectively. Patient characteristics at highest risk of simultaneously experiencing these three symptoms included: those with lung cancer, late stage cancer, existing chronic conditions such as osteoarthritis, mood disorder, hypertension, diabetes, and coronary disease. Patients with over a 40% risk of severe pain also had over a 70% risk of depression, and over a 55% risk of poor well‐being. Our ANN model was able to simultan...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research