Amelioration of Levetiracetam- induced behavioral side effects by Pyridoxine-Randomized double blinded controlled study

Levetiracetam is a relatively new generation antiseizure drug approved for the treatment of focal and generalized seizures. Despite its favorable side effect profile and minimal drug-drug interactions, neuropsychiatric side effects are reported in up to 13% of children. A few case series have suggested that supplementation of pyridoxine may mitigate these side effects, but controlled trials are lacking. To address this issue, a randomized interventional study was carried out in a pediatric tertiary hospital to qualify and quantify the potential beneficial effect of pyridoxine in attenuating the neuropsychiatric side effects of Levetiracetam in children.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Research Paper Source Type: research