Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2
In conclusion, our studies disclosed the chemopreventive effect of FA supplementation on hepatocarcinogenesis, which partial attributed to the inhibition of LCN2 by regulating histone methylation in promoter. Our results provide a potential mechanism of the chemoprevention of FA supplementation on tumorigenesis of HCC and may be helpful in developing treatment target against HCC.PMID:33659047 | PMC:PMC7899549 | DOI:10.18632/oncotarget.27136
Source: Oncotarget - Category: Cancer & Oncology Authors: Yin-Ling Zhang Geng Xue Hui Miao Chuan-Chuan Zhou Shu-Han Sun Yi Zhang Source Type: research
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