Identification of differentially expressed genes in synovial tissue of osteoarthritis based on a more robust integrative analysis method

ConclusionsSeventy DEGs were finally identified with a more robust integrative analysis method.JUN,IL6,VEGFA,MYC, andEGR1 were identified as hub genes in the development of OA.Key Points• 76 overlapping DEGs were detected from the intersection of DEGs in GSE55457, GSE12021, and GSE55235.• 242 DEGs were identified by integrating four series using Sva package.• 72 common DEGs were finally identified based on the overlapping DEGs and the integrated DEGs.• JUN, IL6, VEGFA, MYC, and EGR1 were identified as hub genes in the development of OA.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research