Regulation of OATP1B1 function by tyrosine kinase-mediated phosphorylation

CONCLUSIONS: A novel kinase-dependent post-translational mechanism of OATP1B1 activation was identified and interference with this process by TKIs can influence the elimination of a broad range of xenobiotic substrates.PMID:33664059 | DOI:10.1158/1078-0432.CCR-21-0023

Source: Clinical Cancer Research - March 5, 2021 Category: Cancer & Oncology Authors: Elizabeth Hayden Mingqing Chen Kyle Z Pasquariello Alice A Gibson James J Petti Shichen Shen Jun Qu Su Sien Ong Taosheng Chen Yan Jin Muhammad Erfan Uddin Kevin M Huang Aviv Paz Alex Sparreboom Shuiying Hu Jason A Sprowl Source Type: research