Primordial GATA6 macrophages function as extravascular platelets in sterile injury

In this study, we used intravital microscopy to show that cavity macrophages in fluid rapidly form thrombus-like structures in response to injury by means of primordial scavenger receptor cysteine-rich domains. Aggregates of cavity macrophages physically sealed injuries and promoted rapid repair of focal lesions. In iatrogenic surgical situations, these cavity macrophages formed extensive aggregates that promoted the growth of intra-abdominal scar tissue known as peritoneal adhesions.

Source: ScienceNOW - March 4, 2021 Category: Science Authors: Zindel, J., Peiseler, M., Hossain, M., Deppermann, C., Lee, W. Y., Haenni, B., Zuber, B., Deniset, J. F., Surewaard, B. G. J., Candinas, D., Kubes, P. Tags: Immunology, Medicine, Diseases, Online Only r-articles Source Type: news