BCAS3-C16orf70 complex is a new actor on the mammalian autophagic machinery

(Tokyo Metropolitan Institute of Medical Science) Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Targeted cargo are engulfed by membranes called autophagosome, then delivered to lysosomes where they are degraded. This process is complex, especially in mammals, with many regulatory factors. Researchers in the Ubiquitin Project of Tokyo Metropolitan Institute of Medical Science (TMIMS) discovered mammalian BCAS3-C16orf70 as novel proteins that associate with the autophagosome membranes via interaction with phosphoinositide. These studies were published in Autophagy.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news