Lowered progesterone metabolite excretion and a variable LH excretion pattern are associated with vasomotor symptoms but not negative mood in the early perimenopausal transition: Study of Women ’s Health Across the Nation

The menopausal transition (MT) is characterized by changes in ovarian function and increasing circulating gonadotropin levels [1 –4] with almost 90% of women experiencing regular menstrual cycles up to the last five years before their final menstrual period (FMP) and over 20% retaining normal ovarian function within one year prior to their FMP [5]. Some women have a form of irregular menstrual cycles well before their FMP, indicating a progressive breakdown of the hypothalamic-pituitary-ovarian (HPO) axis with increased symptoms.

Source: Maturitas - March 5, 2021 Category: Primary Care Authors: Daniel S. McConnell, Sybil L. Crawford, Nancy A Gee, Joyce T. Bromberger, Rasa Kazlauskaite, Nancy E. Avis, Carolyn J. Crandall, Hadine Joffe, Howard M. Kravitz, Carol A. Derby, Ellen B. Gold, Samar R. El Khoudary, Sioban Harlow, Gail A. Greendale, Bill L Source Type: research