Peripheral neuropathy due to neuroborreliosis: Insensitivity for CXCL13 as early diagnostic marker

Lyme borreliosis is a multi-organ disease primarily transmitted by ticks. The condition is endemic in different parts of Europe and North America, and is caused by the spirochetes Borrelia burgdorferi sensu stricto, Borrelia garinii and Borrelia afzelii. Nervous system manifestations termed Lyme neuroborreliosis (LNB) are seen in 10 –15% of all borrelia infections in adults. The most common manifestations are meningoradiculitis and cranial neuritis (Summer and Rupprecht, 2019). Rarer neurological complications include brain and spinal cord involvement, cerebral vasculitis and peripheral neuropathies (Moser, Bubel et al.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research

Related Links:

This study aimed to evaluate in vitro and in vivo the wound healing effects of babassu oil. In vitro, babassu oil increased the migration of L929 fibroblasts, inhibited the production of nitric oxide by LPS-stimulated peritoneal macrophages, and increased the levels of INF-γ and IL-6 cytokines production. In vivo, babassu oil accelerated the healing process in a full-thickness splinted wound model, by an increase in the fibroblasts number, blood vessels, and collagen deposition in the wounds. The babassu oil also increased the recruitment of inflammatory cells into the wound site and showed an anti-inflammatory effec...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
CONCLUSION: Birdshot retinochoroidopathy can be found in Hispanic patients. Our study suggests that the characteristics upon presentation in Hispanics may be similar to those of Caucasian cohorts. PMID: 33031692 [PubMed - as supplied by publisher]
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Conclusions. The nerve roots of CIDP, Charcot-Marie-Tooth disease type-1, and polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome were difficult to distinguish by MRN. Atypical CIDP patients had less nerve root injury compared with typical CIDP patients. MRN of either the brachial plexus or the lumbosacral plexus had a high diagnostic accuracy for CIDP, and it is not necessary to perform both parts of the examination. Level of Evidence: 2
Source: Spine - Category: Orthopaedics Tags: DIAGNOSTICS Source Type: research
ConclusionsWith the experience we gained from our recent studies, we think that miRNA-204 may be a significant biomarker in autoimmune diseases. Our study is the first study between IgAV and miRNAs in children. More studies are needed to reveal this relationship.Key Points•This is the first paper to show the relationship between miRNAs and childhood IgAV.•It will provide a new perspective to evaluate the pathogenesis of the disease.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Condition:   Chemotherapy-induced Peripheral Neuropathy Intervention:   Drug: Cannabidiol 100 MG/ML Sponsors:   Zealand University Hospital;   University of Copenhagen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Asymptomatic VL is a concern, considering the risk of transmission in highly endemic areas due to human-to-human transmission. The aim of this study was to report the sero-epidemiological prevalence in Bihar, India, a highly endemic area of VL, using the leishmanin skin test (LST) and the direct agglutination test (DAT). This was a cross-sectional study performed in Muzaffarpur, Bihar, India. Relatives of patients with VL were tested by LST and DAT. Other epidemiological data were evaluated and correlated with tests results. Forty individuals (either previous or current patients), and 109 household contac...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Triatoma brasiliensis Neiva, 1911 and Triatoma pseudomaculata Corrêa and Espínola, 1964 (Hemiptera, Reduviidae, Triatominae) in rural communities in Northeast Brazil. Rev Inst Med Trop Sao Paulo. 2020;62:e74 Authors: Ferreira ALDS, Santana MA, Santos LVBD, Monteiro DP, Campos JHF, Sena LLJ, Mendonça VJ Abstract Chagas disease is an important endemic morbidity in Latin America affecting millions of people in the American continent. It is caused by the protozoan Trypanosoma cruzi, and transmitted through the feces of the insect vector belonging to the subfamily Triatominae. The prese...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Condition:   Chemotherapy-induced Peripheral Neuropathy Intervention:   Drug: Cannabidiol 100 MG/ML Sponsors:   Zealand University Hospital;   University of Copenhagen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Reply to: Comment on: "Microscopic polyangiitis: clinical characteristics and long-term outcomes of 378 patients from the French Vasculitis Study Group Registry'' by Nguyen et al. Clin Exp Rheumatol. 2020 Sep 29; Authors: Nguyen Y, Puéchal X PMID: 33025896 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Bilgin E, Karadağ Ö PMID: 33025879 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
More News: Borrelia | Brain | Endemics | Infectious Diseases | Lyme Disease | Men | Neurology | Peripheral Neuropathy | Vasculitis