Monitoring of cardiac biomarkers and vitamin D concentration in response to calcium infusion in Darehshori horses

AbstractCalcium is an essential mineral and plays a direct role on cardiac muscle activities when given intravenously. The aim of the present study was to determine the effects of calcium infusion on serum cardiac biomarkers and vitamin D concentration in Darehshori horses. Calcium infusion was made once a week, and blood samples were taken before and 1 h after to determine serum cardiac troponin I, creatine kinase myocardial band (CK-MB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), calcium, and vitamin D changes up to four consecutive weeks. Increases in blood calcium along with suppression of serum vitamin D concentrations were prominent findings of this study (p< 0.05). The presence of a positive and significant correlation between LDH/CK-MB, ALP/CK-MB, and LDH/ALP and also a negative correlation between Ca/Vit D (p< 0.05) were other findings of the present research.In response to calcium, P wave shape was changed and became biphasic. PR segment, PR interval, and QRS complex were significantly increased, while ST segment and T wave amplitude decreased (p< 0.05). Normal negative and monophasic T waves became biphasic ( −/+) and in some cases monophasic and positive. In addition, Ta wave (35.71%) and such transient physiological arrhythmias (except for atrial premature complex) were recorded.It is concluded that calcium infusion for four consecutive weeks is well-tolerated but may lead to vitamin D suppression and increase of some cardiac biomarkers l...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research