Locally advanced tongue squamous cell carcinoma in epidermolysis simplex bullosa patient: a therapeutic conundrum

Ann R Coll Surg Engl. 2021 Mar;103(3):e85-e87. doi: 10.1308/rcsann.2020.7080.ABSTRACTEpidermolysis bullosa simplex (EBS) is a debilitating condition affecting the skin and mucous membranes that is characterised by frequent ulceration and blistering on trivial trauma. In EBS, oral cavity mucosal injuries lead to a high propensity for developing squamous cell carcinomas. Locally advanced tongue carcinoma arising in this background presents a challenging therapeutic conundrum. To our knowledge, this is the first case of aggressive locally advanced tongue carcinoma that has developed sporadically in a patient with EBS and no family history. Routine screening of oral mucosal lesions will lead to early detection and timely management of this debilitating condition.PMID:33645266 | DOI:10.1308/rcsann.2020.7080
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Source Type: research