Peripheral blood cultured mast cells: Phenotypic and functional outcomes of different culture protocols

CONCLUSION: Four weeks of culture with IL-6 are sufficient to generate sizeable numbers of human mast cells from blood progenitors, thereby enabling simultaneous exploration of allergen-specific sIgE/FcεRI cross-linking and non-specific activation via MRGPRX2.PMID:33647250 | DOI:10.1016/j.jim.2021.113003

Source: Journal of Immunological Methods - March 1, 2021 Category: Allergy & Immunology Authors: Jessy Elst Vito Sabato Marie-Line M van der Poorten Margaretha Faber Athina L Van Gasse Leander P De Puysseleyr Chris H Bridts Christel Mertens Michel Van Houdt Marcus Maurer Margo M Hagendorens Didier G Ebo Source Type: research