Independent and interactive associations of season, dietary vitamin D, and vitamin D-related genetic variants with serum 25(OH)D in Korean adults aged 40 years or older

In conclusion, season, dietary vitamin D intake, and four SNPs in GC, CYP2R1, and DHCR7 are independently and rs10500804-CYP2R1 is interactively associated with serum 25(OH)D concentration. Serum 25(OH)D is influenced by genotype of rs10500804-CYP2R1 in summer/fall when sunlight exposure is high, while dietary vitamin D intake is an important determinant of serum 25(OH)D during the seasons with low cutaneous vitamin D synthesis.PMID:33642417 | DOI:10.1507/endocrj.EJ20-0519

Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Authors: Jiseon Lee Hye Won Woo Jihye Kim Min-Ho Shin InSong Koh Bo Youl Choi Mi Kyung Kim Source Type: research