RAS as a positive predictive biomarker: focus on lung and colorectal cancer patients
Rat sarcoma (RAS) oncogenes have intensively been investigated during the last decades. Taking into account all human tumours, Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) gene is the most frequently mutated (about 22%) among the three isoforms, followed by Neuroblastoma RAS Viral Oncogene Homolog (NRAS) (8%) and Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS) (3%). In the last years, careful attention has been paid on KRAS and NRAS gene mutations in non –small-cell lung cancer (NSCLC) and colorectal cancer (CRC) patients because of their prognostic and predictive roles.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Umberto Malapelle, Francesco Passiglia, Chiara Cremolini, Maria Lucia Reale, Francesco Pepe, Pasquale Pisapia, Antonio Avallone, Diego Cortinovis, Alfonso De Stefano, Matteo Fassan, Gabriella Fontanini, Domenico Galetta, Calogero Lauricella, Angela List à Tags: Review Source Type: research
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