Synaptophysin expression in V600EBRAF-mutated advanced colorectal cancers identifies a new subgroup of tumours with worse prognosis

Neuroendocrine differentiation has been extensively associated with worse prognosis and to mechanisms of therapy resistance in several epithelial cancers. A high prevalence of neuroendocrine differentiation was recently described in V600EBRAF-mutated (BRAFmt) metastatic colorectal cancers (mCRCs) but no data are available about its prognostic impact in this setting.

Source: European Journal of Cancer - February 16, 2021 Category: Cancer & Oncology Authors: Matteo Fassan, Massimo Milione, Giulia Maddalena, Chiara Cremolini, Marta Schirripa, Filippo Pietrantonio, Nicoletta Pella, Emanuela Dell ’Aquila, Elisa Sperti, Clizia Zichi, Francesca Bergamo, Marco Volante, Alessandra Boccaccino, Federica Morano, Fran Tags: Original Research Source Type: research