Nigeria: Kaduna Teaching Hospital to Set Up in-Vitro Fertilisation Unit

[Vanguard] The Barau Dikko Teaching Hospital Kaduna, has concluded plans to set up In-Vitro Fertilisation (IVF) unit through a Public Private Partnership arrangement.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news

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CONCLUSIONS: MiR-30d-5p and SOCS1 may be potential biomarkers for endometrial receptivity. Changes in pinopode development and abnormal expression of miR-30d-5p, SOCS1 and LIF pathway in the endometrium could be the reasons for implantation failure.PMID:34496883 | DOI:10.1186/s12958-021-00820-2
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Source Type: research
CONCLUSIONS: We are uncertain whether intravenous atosiban improves pregnancy outcomes for women undergoing assisted reproductive technology. This conclusion is based on currently available data from seven RCTs, which provided very low- to low-certainty evidence across studies. We could draw no clear conclusions about subcutaneous barusiban, based on limited data from one RCT. Further large well-designed RCTs reporting on live births and adverse clinical outcomes are still required to clarify the exact role of atosiban and barusiban before ET. Oral nolasiban appears to improve clinical pregnancy rate but not live birth rat...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
AbstractStudy questionWhat are the epistemic and ethical considerations of clinically implementing Artificial Intelligence (AI) algorithms in embryo selection?Summary answerAI embryo selection algorithms used to date are “black-box” models with significant epistemic and ethical issues, and there are no trials assessing their clinical effectiveness.What is known alreadyThe innovation of time-lapse imaging offers the potential to generate vast quantities of data for embryo assessment. Computer Vision allows image data to be analysed using algorithms developed via machine learning which learn and adapt as they are...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionIs there a difference in treatment outcome between gonadotrophin releasing hormone (GnRH) pump or hMG for women with Type 1 anovulation undergoing ovulation induction?Summary answerTreatment with GnRH was more efficient compared to hMG, with fewer number of cycles to pregnancy, fewer days of stimulation and fewer cycle cancellations.What is known alreadyWhilst there is a lot of information on ovulation induction in WHO type II anovulation (PCOS), type 1 anovulation is under-represented in research. WHO type 1 anovulation is characterised by low pituitary gonadotrophins and oestradiol. Treatment option...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
This study is part of a completed multi-centre randomised placebo-controlled trial (IMPLANT 1 – NCT02310802) in IVF patients (n = 247) carried out in 2015. Our study retrospectively assessed a sub-set of patients with good quality TVUS recordings to evaluate their mechanical uterine motion that were randomised to receive either nolasiban 900mg (n = 39) or placebo (n = 42).Participants/materials, setting, methodsSubjects were
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionAre obstetric/perinatal outcomes different in singleton pregnancies following blastocyst-stage embryo transfer when compared to cleavage-stage embryo transfer and have results changed over time?Summary answerPregnancies following blastocyst are consistently associated with higher risk of large for gestational age and lower risk of small for gestational age babiesWhat is known alreadyExtended embryo culture to blastocyst-stage is widely used to select best embryos in in vitro fertilisation (IVF) cycles to improve pregnancy rates. Transfer of blastocyst-stage embryos is increasing with this being the de...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionWhat are a woman ’s contraceptive needs after successful in vitro fertilisation (IVF) pregnancy? and how should services respond to help prevent unintended pregnancies?Summary answerWomen who have IVF pregnancies require tailored, postnatal contraception counselling. Services must provide evidence-based information about the risks of spontaneous conception to engage them effectively.What is known alreadyWomen undergoing IVF are an increasingly heterogeneous group with a wide range of causative subfertility factors. Furthermore, increasingly, women are accessing treatment primarily for reasons ot...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionDoes human embryo culture in different IVF culture media lead to DNA methylation alterations in IVF offspring?Summary answerGenome-wide analyses identified no significant DNA methylation differences between culture medium groups in IVF children (neonates or 9-year olds) from two culture media studies.What is known alreadyDuring in vitro fertilisation (IVF) treatments, embryos undergo preimplantation development in an artificial environment, while concurrently undergoing epigenetic reprogramming. Adversity during this period, such as peri-conception calorie restriction, has been linked to persistent DN...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionDoes endometriosis affect live birth following donor oocyte recipient versus autologous in vitro fertilisation (IVF) cycle.Summary answerThere was no significant difference in the live birth rate (LBR) in women with endometriosis undergoing donor oocyte recipient versus autologous IVF cycle.What is known alreadyFor infertile women with endometriosis, IVF is often considered as a treatment option. Lower implantation and pregnancy rates have been observed following IVF in women with endometriosis when compared to tubal factor infertility. It has been debated that lower pregnancy rates following IVF in e...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionDoes endometriosis affect live birth following donor oocyte recipient versus autologous in vitro fertilisation (IVF) cycle.Summary answerThere was no significant difference in the live birth rate (LBR) in women with endometriosis undergoing donor oocyte recipient versus autologous IVF cycle.What is known alreadyFor infertile women with endometriosis, IVF is often considered as a treatment option. Lower implantation and pregnancy rates have been observed following IVF in women with endometriosis when compared to tubal factor infertility. It has been debated that lower pregnancy rates following IVF in e...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
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