Impact of pre-transplantation minimal residual disease (MRD) on the outcome of Allogeneic hematopoietic stem cell transplantation for acute leukemia

CONCLUSION: Pre-transplantation MRD positive status is a risk factor for survival and prognosis after HSCT. Upon this, emphasis should be put on (1) screening more efficient chemo regimen with targeted agents, to help patients reach and keep MRD- status before transplantation; (2) designing better management with different GvHD prophylaxis treatment, timely disease monitoring and preemptive intervention on relapse.PMID:33648437 | DOI:10.1080/16078454.2021.1889162

Source: Hematology - March 2, 2021 Category: Hematology Authors: Xing Shen Jing Pan Chenchen Qi Yuan Feng Hanxin Wu Sixuan Qian Hua Lu Lijuan Chen Jianyong Li Kourong Miao Hairong Qiu Han Zhu Source Type: research