Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice

Severe fibrosis often leads to significant mortality as a result of liver failure and cirrhosis. Recent evidences arising in the Journal of Hepatology etc shed light on the role of mechanosensing Hippo/YAP/TAZ pathway during hepatic fibrosis1-5. Those studies suggested that YAP/TAZ pathway was activated in various mouse models of liver fibrosis and human fibrotic liver. However, conflicting data exist for both positive and negative regulation of YAP/TAZ pathway in liver fibrogenesis. The study by Liu et al.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research