Urine-Derived Extracellular Vesicle miRNAs as Possible Biomarkers for and Mediators of Necrotizing Enterocolitis: A Proof of Concept Study

Early-stage symptomology of necrotizing enterocolitis (NEC) is similar in presentation to non-NEC sepsis, though the treatment plans differ based on antibiotic administration and withholding of feeds. Improved diagnostics for NEC differentiation would allow clinicians to more rapidly set individual patients on a targeted treatment path. Extracellular vesicle-derived miRNAs, have previously demonstrated efficacy as disease biomarkers. To determine if these miRNAs are differentially-expressed in NEC infants, we performed transcriptomic analysis of urine-derived extracellular vesicle-derived miRNAs.

Source: Journal of Pediatric Surgery - March 2, 2021 Category: Surgery Authors: Jeffrey D. Galley, Pamela Mar, Yijie Wang, Rachel Han, Adrian Rajab, Gail E. Besner Source Type: research