Can We Avoid Axillary Lymph Node Dissection (ALND) in Patients with 1 –2 Positive Sentinel/Low Axillary Lymph Nodes (SLN/LAS+) in the Indian Setting?

AbstractThe ACOSOG Z0011 study, heralded as a “practice changing” trial, suggested that women with T1–2 breast cancer with 1–2 SLN+, undergoing breast conservation therapy, need not be offered further ALND. However, whether these results are applicable to all women in the Indian setting, it remains debatable. A retrospective audit of al l cN0 operated from 2013 to 2018 was conducted. We analyzed the percentage of additional LN positive (LN+) in the ALND group and compared it to the ACOZOG Z11 trial. Of the 2350 cN0 with EBC who underwent LAS, 687 (29%) had positive lymph nodes on final histopathology. Five hundred ninety-seven (86. 9%) patients had 1–2 LN+, 40 (5.8%) patients had 3 LN+, and 50 (7.3%) had 4 or more nodes positive. Demographic features in the ACOSOG Z11 are different from those in our study, looking at ACOZOG Z11 versus our cohort—median pT 1.7 cm versus 3 cm, 45% micrometastasis versus 99.16% macrometasta sis, and 28–30% grade 3 tumors versus 73.7%. In our cohort 31.82% of the 1–2 LN positive had additional LN+ on ALND. Keeping in mind the difference in clinicopathological features between our cohort and that of ACOZOG Z0011 and that 31.82% of women had additional LN+ on ALND, it may not be appro priate to apply the results of the ACOSOG Z0011 trial directly to our general population. Possibly, only a select subset of patients who match the trial population of the ACOSOG Z11 could be offered observation of the axilla and validated nomograms c...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research