Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen–Friedenreich conjugate

Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB00007A, PaperXuanjun Wu, Hunter McFall-Boegeman, Zahra Rashidijahanabad, Kunli Liu, Christian Pett, Jin Yu, Manuel Schorlemer, Sherif Ramadan, Sandra Behren, Ulrika Westerlind, Xuefei Huang A MUC1 glycopeptide bearing an unnatural β-glycosyl bond between the glycan and the peptide backbone was synthesized. The mimic can induce high levels of IgG antibodies cross-recognizing cancer cells expressing the native MUC1 glycoprotein. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research