New Insights into Stroke Prevention and Treatment: Gut Microbiome

Cell Mol Neurobiol. 2021 Feb 26. doi: 10.1007/s10571-021-01047-w. Online ahead of print.ABSTRACTStroke, a lethal neurological disease, accounts for a grave economic burden on society. Despite extensive basic and clinical studies on stroke prevention, a precise effective treatment approach for stroke at this stage remains unavailable. The majority of our body's gut microbiota plays a vital role in food digestion, immune regulation, and nervous system development, which is highly associated with the development of some diseases. Multiple clinical studies have documented variation in the composition of gut microbiota between stroke patients and healthy counterparts. Moreover, the intervention of intestinal symbiotic microorganisms via several mechanisms plays an active role in stroke prognosis. In the prevention and treatment of stroke, the gut microbiota gives off a seductive glow, this is a promising therapeutic target. This paper summarizes the current knowledge of stroke and gut microbiota, and systematically describes the possible mechanisms of interaction between stroke and gut microbiota, the relationship between stroke-related risk factors and gut microbiota, and the treatment of gut flora using microorganisms. Thus, it could valuably elucidate the correlation of gut microbiota with stroke incidence, providing stroke researchers with a new strategy for stroke prevention and treatment by regulating gut microbiota.PMID:33635417 | DOI:10.1007/s10571-021-01047-w

Source: Cellular and Molecular Neurobiology - February 26, 2021 Category: Cytology Authors: Linna Zhao Liji Yang Yuying Guo Jie Xiao Junping Zhang Shixin Xu Source Type: research