Enrichment of IGF-1R and PPAR γ signalling pathways in orbital inflammatory diseases: steps toward understanding pathogenesis

CONCLUSIONS: Although OID includes a heterogenous group of pathologies, TAO, GPA, sarcoidosis and NSOI share enrichment of common gene signalling pathways, namely IGF-1R, PPARγ, adipocytokine and AMPK. Pathway analyses of gene expression suggest that other forms of orbital inflammation in addition to TAO may benefit from blockade of IGF-1R signalling pathways.PMID:33637620 | DOI:10.1136/bjophthalmol-2020-318330

Source: The British Journal of Ophthalmology - February 27, 2021 Category: Opthalmology Authors: Rohan Verma Dongseok Choi Allison J Chen Christina A Harrington David J Wilson Hans E Grossniklaus Roger A Dailey John Ng Eric A Steele Stephen R Planck Bobby S Korn Don Kikkawa Craig N Czyz Jill A Foster Michael Kazim Gerald J Harris Deepak P Edward Hail Source Type: research