Prospective study for establishing minimal clinically important differences in patients with surgery for lower extremity metastases

CONCLUSION: This prospective study successfully defined a MCID for PROMIS Pain Interference of 7.5 (3.4-12), PROMIS Physical Function of 4.1 (0.6-7.6), and Global Physical Health of 4.2 (2.0-6.6) in patients with (impending) pathological fractures due to osseous metastases in the lower extremity; no MCID could be established for PROMIS Global Mental Health. Defining a narrower MCID value for each subpopulation requires a large, prospective, multicenter study. Nevertheless, the provided MCID values allow guidance to clinicians to evaluate the impact of surgical treatment on a patient's QoL.LEVEL OF EVIDENCE: Level II Diagnostic study.PMID:33630699 | DOI:10.1080/0284186X.2021.1890333

Source: Acta Oncologica - February 25, 2021 Category: Cancer & Oncology Authors: M E R Bongers O Q Groot Q C B S Thio J A M Bramer J J Verlaan E T Newman K A Raskin S A Lozano-Calderon J H Schwab Source Type: research