Early T-cell precursor acute lymphoblastic leukemia and T/myeloid mixed phenotype acute leukemia possess overlapping characteristics and both benefit from CAG-like regimens and allogeneic hematopoietic stem cell transplantation

In the World Health Organization (WHO) classification, early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) and T/myeloid mixed phenotype acute leukemia (T/M-MPAL) are classified as distinct entities. The most immature intrathymic T cell progenitors retain myeloid characteristics, and early T cell progenitors can function as the cell of origin of T/M-MPAL.1-3 In clinical practice, ETP-ALL and T/M-MPAL are closely related entities because they have similar immunophenotypes and genomic alterations,4,5 as well as significantly worse outcomes than other classes of T-cell acute lymphoblastic leukemia (T-ALL).

Source: Biology of Blood and Marrow Transplantation - February 27, 2021 Category: Hematology Authors: Sining Liu, Qingya Cui, Haiping Dai, Baoquan Song, Wei Cui, Shengli Xue, Huiying Qiu, Miao Miao, Zhengming Jin, Caixia Li, Chengcheng Fu, Ying Wang, Aining Sun, Suning Chen, Xiaming Zhu, Depei Wu, Xiaowen Tang Source Type: research