Clinical utility of polygenic risk scores for predicting NAFLD disorders

Non-alcoholic fatty liver disease (NAFLD) causes severe disorders, such as vascular diseases, cirrhosis and hepatocellular carcinoma (HCC) in a large proportion of individuals in certain populations, such as overweight or obese individuals, and those with diabetes. These disorders are associated with abnormal fat accumulation in the liver, which may or may not lead to inflammation (steatohepatitis, NASH) and abnormal extracellular matrix deposition (fibrosis) in damaged tissues. Several causes of abnormal fat accumulation in the liver have been identified.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research