Txnip C247S mutation protects the heart against acute myocardial infarction
Thioredoxin-interacting protein (Txnip) is a novel molecular target with translational potential in diverse human diseases. Txnip has several established cellular actions including binding to thioredoxin, a scavenger of reactive oxygen species (ROS). It has been long recognized from in vitro evidence that Txnip forms a disulfide bridge through cysteine 247 (C247) with reduced thioredoxin to inhibit the anti-oxidative properties of thioredoxin. However, the physiological significance of the Txnip-thioredoxin interaction remains largely undefined in vivo.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Yoshinobu Nakayama, Nobuhiro Mukai, Bing F. Wang, Kristen Yang, Parth Patwari, Richard N. Kitsis, Jun Yoshioka Source Type: research