Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system

In conclusion, variants in genes influencing NAFLD exhibit pleiotropic associations with hematologic traits, particularly platelet count. Likewise, significant enrichment of related genes with variants influencing platelet traits was noted in metabolic-related pathways. Hence, this approach yields novel mechanistic insights into NAFLD pathogenesis.PMID:33584064 | PMC:PMC7852588 | DOI:10.3748/wjg.v27.i4.305
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Source Type: research