High-normal alanine aminotransferase is an indicator for liver histopathology in HBeAg-negative chronic hepatitis B

ConclusionHBeAg-negative CHB patients with normal ALT and low HBV DNA level (<  2000 IU/mL) were suggested to perform liver biopsy or noninvasive methods for histopathology assessment, then to be determined for antiviral therapy. ALT >  20 U/L and HBV DNA ≥ 2000 IU/mL are good independently predictive factors for evaluating significant liver histopathology for HBeAg-negative CHB patients with normal ALT.Clinical Trials RegistrationChinese Clinical Trial Registry (ChiCTR-IOR-14005474).Graphic Abstract
Source: Hepatology International - Category: Infectious Diseases Source Type: research