Chances of Finding Matched Unrelated Donors for Saudi Patients in Need of Hematopoietic Stem Cell Transplantation

Hematopoietic stem cell transplantation (HSCT) is potentially a curative therapy for many malignant and non-malignant hematological disorders [1]. Patients without a related donor can receive stem cells from a matched unrelated donor (MUD). For successful HSCT, the donor and recipient should have optimal human leukocyte antigens (HLAs) matching, including HLA-A, HLA-B, HLA-C and HLA-DRB1 (8/8) [2]. Transplants with a mismatch at one of these loci has been shown to be associated with a higher mortality risk [2,3].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research