Volume Load-Induced Right Ventricular Failure in Rats Is Not Associated With Myocardial Fibrosis

ConclusionsIn the ACS rat model, long-term volume load was initially well tolerated at 1 month and 3 months, but induced overt clinical signs of end-stage RV failure at 6 months. However, no myocardial fibrosis or increased pro-fibrotic signaling had developed. These findings indicate that myocardial fibrosis is not involved in the transition from compensated to decompensated RV dysfunction in this model.
Source: Frontiers in Physiology - Category: Physiology Source Type: research