Searching for the origin of the myofibroblast one cell at a time

Chronic kidney disease (CKD), regardless of the initial injury, is often characterized by relentless progression with ultimate development of tubular atrophy, interstitial fibrosis, and glomerulosclerosis. The extent of tubulointerstitial fibrosis is the morphologic parameter most closely associated with decreased glomerular filtration rate (1). Interstitial fibrosis and tubular atrophy (IF/TA) almost invariably develop in parallel and increased IF/TA is a morphologic indicator of poor prognosis across the full spectrum of kidney diseases.

Source: Kidney International - February 25, 2021 Category: Urology & Nephrology Authors: Agnes B. Fogo Tags: nephrology digest Source Type: research