GSE167547 Clinical and molecular differentiation between malignant rhabdoid tumor of normal tissue: A two-case report

Contributors : Chenghao Zhanghuang ; Shuo Chen ; Li Li ; Zhen Yang ; Yucheng Xie ; Jiwei Li ; Haoyu Tang ; Xiaoli He ; Liuyi Dong ; Bing YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPreoperative B-scan ultrasonography and Computed Tomography (CT) examination in 2 cases suggested that nephroblastoma . Treated with radical nephrectomy after general anesthesia. After operation,MRTK diagnosis by pathological examination. Regular chemotherapy 7 courses(Child 1) and 12 courses(Child 2),followed up for 2 years(Child 1) and 3 years and 1 month(Child 2), without symptoms. RNA-seq results showed 2203 differential genes (DEGs) in the kidney tissue of children with MRTK compared to normal tissue. GO analysis suggested that most DEGs participate in protein binding. KEGG results showed that the DEGs were mainly involved in the PI3K-Akt signaling pathway and microRNA-related proteins.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research