Comparison of DCE-MRI of murine model cancers with a low dose and high dose of contrast agent

Dynamic contrast enhanced (DCE) MRI is routinely used clinically for detection and diagnosis of breast cancers, as well as evaluating response to cancer therapies [1 –5]. DCE-MRI is usually acquired with a rapid T1-weighted (T1w) gradient echo sequence before, during and after IV bolus injection of Gadolinium based contrast agents (GBCAs) [6]. Normally, a dose of 0.1 mmol/kg of the body weight GBCA is given to patients. During cancer treatment, DCE-MRI may be performed multiple times for evaluation of treatment response [1,5,7].
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research