Economic and Clinical Burden of Virus-Associated Hemorrhagic Cystitis in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation in the United States

Allogeneic hematopoietic stem cell transplantation (allo-HCT) is often the only curative option for both malignant and nonmalignant diseases.1, 2 During the period of immune recovery after allo-HCT, viral infections, which are normally controlled by T-cell immunity, are a major cause of morbidity and mortality.3-6 A recent retrospective study of 404 allo-HCT recipients showed that detection of multiple viruses was common, including BK virus (BKV), cytomegalovirus (CMV), adenovirus (AdV), Epstein –Barr virus (EBV) and human herpesvirus-6 (HHV-6) and demonstrated an association between the cumulative burden of virus exposure and increased mortality.

Source: Biology of Blood and Marrow Transplantation - February 25, 2021 Category: Hematology Authors: Joseph McGuirk, Clint Divine, Seung Hyun Moon, Aastha Chandak, Zhiji Zhang, Genovefa A. Papanicolaou Source Type: research