Genomic scans for selection signatures revealed candidate genes for adaptation and production traits in a variety of cattle breeds

Genomics. 2021 Feb 18:S0888-7543(21)00066-5. doi: 10.1016/j.ygeno.2021.02.009. Online ahead of print.ABSTRACTDomestication and selection are the major driving forces responsible for the determinative genetic variability in livestock. These selection patterns create unique genetic signatures within the genome. BovineSNP50 chip data from 236 animals (seven indicine and five taurine cattle breeds) were analyzed in the present study. We implemented three complementary approaches viz. iHS (Integrated haplotype score), ROH (Runs of homozygosity), and FST, to detect selection signatures. A total of 179, 56, and 231 regions revealed 518, 277, and 267 candidate genes identified by iHS, ROH, and FST methods, respectively. We found several candidate genes (e.g., NCR3, ARID5A, HIST1H2BN, DEFB4, DEFB7, HSPA1L, HSPA1B, and DNAJB4) related to production traits and the adaptation of indigenous breeds to local environmental constraints such as heat stress and disease susceptibility. However, further studies are warranted to refine the findings using a larger sample size, whole-genome sequencing, and/or high density genotyping.PMID:33610795 | DOI:10.1016/j.ygeno.2021.02.009

Source: Genomics - February 21, 2021 Category: Genetics & Stem Cells Authors: K A Saravanan Manjit Panigrahi Harshit Kumar Subhashree Parida Bharat Bhushan G K Gaur Triveni Dutt B P Mishra R K Singh Source Type: research