Distribution of IgG subclass anti-nuclear antibodies (ANAs) in systemic lupus erythematosus

CONCLUSIONS: First, we demonstrated that the ANA IgG subclasses were diagnostic tools in SLE patients. Furthermore, HA IgG ANAs might affect the distribution of ANA IgG3 and IgG4. Moreover, ANA IgG3 might play a particular role in the activity of SLE disease and therapy. Therefore, an altered ANA IgG subclass distribution might be a risk factor influencing the inflammatory process in SLE.PMID:33622075 | DOI:10.1177/0961203321995242

Source: Lupus - February 24, 2021 Category: Rheumatology Authors: Yanli Zeng Yan Zhang Qinggui Chen Qinghe Huang Yiqiang Lin Xuelian Wang Jia Jia Wang Longcan Jiang Yun Xiao Source Type: research