CD52/GPI-negative T-cells are enriched for alloreactive specificity and predict acute GvHD after stem cell transplantation.

Allogeneic haemopoietic stem cell transplantation (HSCT) is an effective treatment for many patients with haematological malignancy and relies substantially on a ‘graft versus leukaemia’ (GvL) effect mediated by the donor immune system [1,2]. GvL is believed to be mediated predominantly by allogeneic T cell recognition of minor histocompatibility antigens expressed by host haemopoietic cells but the alloreactive response can also mediate graft versus hos t disease (GvHD) through recognition of peptides on other tissues [3,4].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research