Increased mitochondrial oxygen consumption in adult survivors of preterm birth

CONCLUSIONS: In conclusion, adults born preterm have higher basal and non-ATP-linked mitochondrial respiration. Similar mitochondrial profiles have previously been documented in diabetics, and may support the increased risk for cardiometabolic disease in adults born preterm.IMPACT: Adults born preterm have higher maximal but also higher basal and non-ATP-linked mitochondrial respiration. Similar mitochondrial profiles have previously been documented in diabetics, and may support the increased risk for cardiometabolic disease in adults born preterm. Prior studies demonstrate a link between perinatal mitochondrial function and risk for development of bronchopulmonary dysplasia. Here, maximal mitochondrial respiration correlates modestly with adult lung function. Peripheral blood mononuclear cell mitochondrial function may be a biomarker of both early lung function and late cardiometabolic risk after preterm birth.PMID:33619358 | DOI:10.1038/s41390-021-01387-9

Source: Pediatric Research - February 23, 2021 Category: Pediatrics Authors: Santosh Kumari Gregory P Barton Kara N Goss Source Type: research