Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA (Vascular Endothelial Growth Factor A)-Induced VE-Cadherin Internalization

CONCLUSIONS: We show that SDC4 is a downstream mediator of VEGFA-induced vascular endothelial cadherin internalization during pathological angiogenesis and a potential target for antiangiogenic therapies.PMID:33596666 | DOI:10.1161/ATVBAHA.121.315941

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 18, 2021 Category: Cardiology Authors: Giulia De Rossi Maria V ähätupa Enrico Cristante Samantha Arokiasamy Sidath E Liyanage Ulrike May Laura Pellinen Hannele Uusitalo-J ärvinen James W Bainbridge Tero A H Jarvinen James R Whiteford Source Type: research