Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes

CONCLUSIONS: These findings suggest that reelin inhibition may provide a novel therapeutic approach to counteract leukocyte or monocyte adhesion as well as extravasation and inhibit the progression of atherosclerosis. This strategy may also be relevant for other diseases that involve leukocyte or monocyte extravasation as a central pathological mechanism, such as multiple sclerosis or arthritis.PMID:33626909 | DOI:10.1161/ATVBAHA.121.316000

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Laurent Calvier Xunde Xian Richard Lee Anastasia Sacharidou Chieko Mineo Philip W Shaul Maria Z Kounnas Shirling Tsai Joachim Herz Source Type: research