Knockout of the < em > NONO < /em > Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury

CONCLUSIONS: NONO was not required for maintaining vascular integrity, but NONO knockout reversed the pathological processes mediated by increased proliferation, migration, and phenotypic switching of VSMCs. The mechanism of these effects involved an interaction of NONO and Erk signaling cascade. Thus, inhibition of NONO may provide a novel therapeutic strategy in cardiovascular disease associated with intimal thickening.PMID:33626912 | DOI:10.1161/ATVBAHA.119.313581

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Xingli Xu Xinghua Xu Yang Mao Lin Lu Jing Ma Tengfei Zheng Jie Zhang Meng Zhang Linlin Meng Lianyue Ma Jing Cheng Wenqiang Chen Hong Jiang Yun Zhang Cheng Zhang Source Type: research