Genetic and molecular subtype heterogeneity in newly diagnosed early- and advanced-stage endometrial cancer

CONCLUSIONS: Our findings demonstrate the molecular heterogeneity within and across histologic types of EC and the increased genomic complexity of advanced-stage ECs. Molecular subtypes are present across EC histologic types and may help stratify EC patients for prognostic and therapeutic purposes.PMID:33622519 | DOI:10.1016/j.ygyno.2021.02.015

Source: Gynecologic Oncology - February 24, 2021 Category: Cancer & Oncology Authors: Arnaud Da Cruz Paula Deborah F DeLair Lorenzo Ferrando Daniel J Fix Robert A Soslow Kay J Park Sarah Chiang Jorge S Reis-Filho Ahmet Zehir Mark T A Donoghue Michelle Wu David N Brown Rajmohan Murali Claire F Friedman Dmitriy Zamarin Vicky Makker Jennifer Source Type: research