Bias and uncertainty of the International Normalized Ratio determined with a whole blood point-of-care prothrombin time test device by comparison to a new International Standard for thromboplastin

Whole blood point-of-care PT/INR test devices, e.g. CoaguChek XS, are calibrated by their manufacturers. In the Netherlands, each new lot of test strips for CoaguChek XS is validated by a group of anticoagulant clinics collaborating with a Coagulation Reference Laboratory. In 2017, a new International Standard for recombinant human thromboplastin (coded rTF/16) has been established by the World Health Organization.

Source: Thrombosis Research - February 24, 2021 Category: Hematology Authors: Antonius M.H.P. van den Besselaar, Claudia J.J. van Rijn, Charmane F. Abdoel, Christa M. Cobbaert Tags: Full Length Article Source Type: research