Efficacy, acceptability, and safety of antidepressants for low back pain: a systematic review and meta-analysis

ConclusionsTreatment of LBP with antidepressants is associated with small reductions in pain intensity and increased odds of stopping treatment for any reason, compared to placebo. The effect on pain is not clinically important. The effect on acceptability warrants consideration. These findings provide Level I evidence to guide clinicians in their use of antidepressants to treat LBP.Trial registrationWe prospectively registered the protocol for this systematic review on PROSPERO (CRD42020149275).
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research