Identification of a new class of HBV capsid assembly modulator

Bioorg Med Chem Lett. 2021 Feb 18:127848. doi: 10.1016/j.bmcl.2021.127848. Online ahead of print.ABSTRACTThe HBV core protein is a druggable target of interest due to the multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly has shown efficacy in clinical trials. Herein is described the identification and hit to lead SAR of a novel series of pyrazolo piperidine HBV capsid assembly modulators.PMID:33610748 | DOI:10.1016/j.bmcl.2021.127848

Source: Bioorganic and Medicinal Chemistry Letters - February 21, 2021 Category: Chemistry Authors: Scott D Kuduk Bart Stoops Richard Alexander Angela M Lam Christine Espiritu Robert Vogel Vincent Lau Klaus Klumpp Osvaldo A Flores George D Hartman Source Type: research