Current Trends in the Therapeutic Strategies for Diabetes Management

Curr Med Chem. 2021 Feb 18. doi: 10.2174/0929867328666210218183914. Online ahead of print.ABSTRACTDiabetes mellitus is one of the fastest growing noncommunicable disease. Diabetes mellitus is causes due to destruction of pancreatic beta cell or due to insulin resistance and characterised by hyperglycaemia. Diabetes imposes a very serious economic crisis as the diabetic drug market is growing very rapidly. Even after very path breaking scientific discoveries, availability of a better healthcare infrastructure, rise in literacy rates, the diabetes burden is continuously spreading in various sections all over the worlds but more especially in low- and middle-income countries. The recent development in scientific discoveries have given a number of new generations of antidiabetic medicines such as sulphonylurea, biguanides, thiazolidinedione, alpha glucosidease inhibitors. All these drugs have proved significant reduction in blood glucose level. There are some new classes of hypoglycaemic drugs have also been developed and reported such as GLP-1 analogous, DPP-IV inhibitors, amylin inhibitors, Peroxisome proliferator activated receptors. There are some active molecules and bioactive substances have been purified from herbs and plants which adds values to the war against diabetes. These phytoconstituents have overturned the drug development and lead identification for drug against diabetes. The review also focusses on some critical area of diabetes with more focus on statin-based d...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research